Reproducibility of scientific studies is a major issue, and a contributing factor is the quality and proper use of reagents. Biocompare, a resource portal for life science reagents/equipment/etc, recently commissioned a documentary about antibody validation. I was interviewed for it. It's a great documentary, with an in-depth look at both the problem and the potential solutions.
I encourage you to watch it if you're using antibodies in your work... If you only want to see what I look and sound like, skip to the 17:30 and 23:49 time points. Enjoy!